It is part of a chain of state highways numbered 200 that extend from Idaho across Montana, North Dakota, and Minnesota, totaling approximately 1,356 miles (2,182 km) long.

MT 200 continues east following the Jocko River for 6 miles (10 km) and borders the CSKT Bison Range until it intersects with US 93 at Ravalli.

The two highways share a 27-mile (43 km) concurrency and travel south I-90, where they head east into Missoula.

MT 200 follows I-90 through Missoula for 14 miles (23 km), with US 93 departing and US 12 joining the route along the way, leaving the interstate near Milltown.

The highway runs parallel to the Blackfoot River and is subject to hazardous driving conditions in the winter, particularly due to black ice.

At Eddie's Corner (near Moore), the routes meet US 191 where MT 3 and US 191 share a common alignment to Harlowton.

MT 200 leaves Sydney and travels northeast for 11 miles (18 km) to Fairview, where it turns east and crosses into North Dakota.