Montefalcone nel Sannio is a comune (municipality) in the Province of Campobasso in the Italian region Molise, located about 35 kilometres (22 mi) north of Campobasso.

Montefalcone nel Sannio borders the following municipalities: Castelmauro, Celenza sul Trigno, Montemitro, Roccavivara, San Felice del Molise.

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