Montfrin (French pronunciation: [mɔ̃fʁɛ̃]) is a commune in the Gard department in southern France.

Montfrin is located between Nîmes and Avignon, 10 km (6.2 mi) from Pont du Gard.

In Roman times, the place was called Mons Ferinus (mountain of the ferocious animals).

The village has attracted celebrities during its history (including François I, Richelieu, Molière), and until the French Revolution, due to the presence of a "healing" spring, the spring of Fontcluse.

A story says that the virtues of the spring were discovered by Charles Martel, who witnessed the healing of wounded soldiers after the battle.