North of 14th Street, the road forms the eastern boundary of Stuyvesant Town and Peter Cooper Village.

Although the East Village designation of this area has received widespread acceptance, many longtime Loisaida residents still consider it part of the Lower East Side, as evidenced by the public art found on the buildings along Avenue C. A bicycle lane has existed on the avenue since 1999.

[4] Avenue C was converted into a two-way boulevard between 18th Street and 23rd Street as part of the development of Stuyvesant Cove Park, which opened in 2002 and resulted in the shifting of the northbound service road of the FDR Drive from the east side to the west side of the elevated viaduct.

[5][6] On October 29th and 30th, 2012, Hurricane Sandy caused extensive damages including this street in specific of many that were flooded out during the storm.

The Public National Bank Building at 106 Avenue C at the corner of East 7th Street (also known as 231 East 7th Street) was built in 1923 as a branch bank, and was designed by Eugene Schoen, a noted advocate of modernism at the time.