Monthureux-le-Sec (French pronunciation: [mɔ̃tyʁø lə sɛk] ⓘ) is a commune in the Vosges department in Grand Est in northeastern France.

The French name Monthureux-le-Sec ("Monthureux the Dry") distinguishes this town from Monthureux-sur-Saône on the Saône River.

Both names derive from Medieval Latin monasteriolum ("little monastery"), as do numerous other locations known as Montreuil and Montreux.

The commune contains the meeting point of the three drainage basins of the rivers Rhône, Rhine and Meuse.

Célestin Gérard, (1821 - 1885) manufacturer of agricultural machinery and inventor of a mobile Threshing machine and of other steam powered implements, was born at Monthureux-le-Sec.