The 'Simbruini' name derives from Simbruvium, a lake formed by the river Anio, situated in the territory of the Aequi; it may derive from Latin sub imbribus ("under the rain").
The Monti Simbruini mark a part of the border between Abruzzo and Lazio.
The range's highest peak is Monte Cotento, at 2,015 metres (6,611 ft) in elevation.
On the Lazio side of the mountain range, between the provinces of Rome and Frosinone, a natural park has been established, the Parco naturale regionale Monti Simbruini.
The regional park and mountains include the comuni (villages) of: Camerata Nuova, Cervara di Roma (Campaegli), Filettino, Jenne, Subiaco (Monte Livata), Trevi nel Lazio and Vallepietra.