Monticello Store and Post Office is a historic general store and post office located at Monticello, Fairfield County, South Carolina, United States.

It may have been built as early as 1820, and is a one-story, frame, weatherboarded, T-shaped building.

The front façade features an undercut gallery with a pedimented gable supported by octagonal wooden columns.

The building was used as a store and post office after the American Civil War until the mid-1960s.

This article about a property in Fairfield County, South Carolina on the National Register of Historic Places is a stub.