At the end of the 14th century, Montisi became an independent comune and so remained until 1777, when it became at the first a frazione of Trequanda, and, after various vicissitudes due to the water supply, of San Giovanni d'Asso.

It was built by the Spedale in 14th century and, when it sold the Grange, the farm was bought by Jacopo Mannucci Benincasa, Secretary of the Grand Duke of Tuscany Peter Leopold.

The last major intervention began in mid-twentieth century, when the parson Elio Benvenuti to the church expanded by building a new apse and the side chapel.

The church has many works of art such as the altar piece "Madonna enthroned with Saints Paul, James, Peter and Louis" by Neroccio di Bartolomeo de' Landi, and the "Crucifixion" painted in the mid-fourteenth century .

It was the first church in the village to be built in the Middle Ages and has been completely restored in Baroque style in 1732 at the behest of the Bishop of Pienza Septimius Cinughi.

The church, then home to several fraternities, was enlarged in the mid-nineteenth century thanks to funding family Mannucci Benincasa: were made in the transept, the new apse, the main altar, the sacristy and the bell tower.

The fifteenth-century crypt, the sacristy and the meeting room are used as a Museum of Sacred Art, with furnishings and objects from the oratory and the church of Saints Flora and Lucilla.

In the meeting room, which is above the sacristy, are preserved ancient missals, the processional statue of Our Lady of Seven Sorrows and a banner painted with the symbol of brotherhood.

The facade on Via Umberto I is characterized by the great portal in solid wood doors with wrought iron frame with carved leaves and marble ashlar.

Every year, on the afternoon of the Sunday closest to 5 August, the feast of Our Lady of the Snows, there is the traditional Giostra di Simone, attended the four quarters of the country, which includes a parade with costumed along the way main race of the flag and a carousel horseback in which you must thread the campanella, a ring placed on the shoulder of the Buratto, a dummy which turns on itself.