The first evidence of continuous human occupation in the area of Monzón comes from Neolithic archaeological remains found in the Sosiles Altos and Peña Lucas deposits.

The area was a key node connecting the cities of Caesaraugusta and Osca with Italy; remains of Roman dwellings have been found in the hills and cells of the Ermita de la Alegría (the Shrine of Joy).

[citation needed] It was also as an important center for joint legislative sessions for the various segments of Aragon, especially between the 13th and 17th centuries because of its location between Zaragoza and Barcelona.

During the 12th century Monzón was ruled by the infant Ramiro de Navarra, Tizón and García Ramírez before his proclamation as King of Navarre among others.

After his father Peter II ("The Catholic") died in the Battle of Muret (1213); the Knights Templar in Monzon served as the young king's guardians and tutors.

In this town the Cardinal Richelieu and Gaspar de Guzmán, Count-Duke of Olivares signed a treaty here, ending the conflict over Valtelline in 1626.

The industrial tradition of Monzón began early in the 20th century with the construction of a sugar factory which later was moved to Jerez de la Frontera.

There are also noteworthy various contests of painting and narrative as well as several cultural concentrations of various kinds and the feast of Saint Barbara martyr in which it is performed the traditional Bautizo del Alcalde (Baptism of the Mayor) and the festivities in honor of Saint Matthew during the week of September 21 and pilgrimage that achieves Easter Monday to the Ermita de la Alegría (Hermitage of the Virgin of the Joy).

In the first one, despite its very little flow, it is remarkable the engineering work in Siphon of the Sosa, a viaduct over the river which flows the Aragon and Catalonia Canal, which was inaugurated in early 20th century by King Alfonso XIII to extend irrigation to the eastern part of the province Monzón is one of the largest agricultural and industrial populations in the region thanks to the Aragon and Catalonia Canal.