The Liberation features two monophonic voltage-controlled oscillators and a polyphonic section that can play organ sounds.

The keyboard is aftertouch-sensitive and the neck features spring-loaded wheels for filter cutoff, modulation, and volume, as well as a ribbon-controlled pitch bend.

A 40-foot cable connects the Liberation to its rackmounted half which houses the power supply and CV/Gate output sockets.

Other artists who have used the instrument include James Brown, Didier Marouani of Space, Tom Coster of Santana, Tommy Cyborg of Chrome, Herbie Hancock, Joy Electric, Danny Peyronel of UFO, Michael Busse of Spider Murphy Gang, Six Finger Satellite, Page McConnell of Phish, and Saga.

Though Devo is commonly associated with the Moog Liberation, the band never used it on stage or in the studio, only in music videos and for a promotional ad for the synthesizer.