The Moon High football team competes in the WPIAL Class AAAAA Allegheny Six Conference, which is made up of South Fayette, Baldwin, Upper St. Clair, Bethel Park, and Peters Township.

[5] In 1998, Moon Tigers won the WPIAL Class AAA Championship at Three Rivers Stadium in Pittsburgh.

[6] The Tigers then went on to the PIAA Class AAA championships in Hershey, only to fall 10–0 to Allentown Central Catholic High School.

[13] The Moon High boys' basketball team made school history, winning three consecutive WPIAL championships – 2004, 2005, 2006.

Moon boy's varsity basketball won the WPIAL 5A final March 1, 2024, their fifth in school history.