He joined the Indian Administrative Service in 1960 and rose to be the Principal Secretary to the Chief Minister of Gujarat.

During this time, he was known as a great orator and debater, and member of the quiz team participating in and winning in several in the College and inter-university competitions.

In 1958, the then Vice-Chancellor, Sir Lakshman Swami Mudaliar appointed him as an Assistant Professor of English in the Presidency College, his alma mater.

He was picked up by the then Finance Minister of India, Morarji Desai, to head his home District of Bulsar (Valsad) for four years.

As Director of Relief, Moosa Raza covered an area of over 50,000 kilometres, travelling by jeep, car, boats, on camel and on horseback.

[6] For a major part of his career Moosa Raza functioned as chairman & managing director of several prestigious industrial and commercial enterprises both at the State and Central levels.

For seven continuous years under his stewardship, the Gujarat State Fertilizer Company won the National Awards for best productivity, safety and industrial relations.

Concurrently, he functioned as the chairman and managing director of the Calico group of Industries, a private sector undertaking under the control of the State Bank of India.

In the wake of the demolition of the Babri Masjid, Moosa Raza was sent as an Advisor to the Governor of Uttar Pradesh where during his tenure, he helped in controlling the law and order situation.

[8] He formulated numerous proposals and policies to liberalise the steel industry of India and set it on the path of expansion and modernisation.

[11] He was chairman of the committee appointed by the Government of J & K to recommend measures to devolve power to the people and control corruption.

He also served on the Government Committee to review the POTA cases in Jammu & Kashmir and Gujarat as well as the Task Force on Socio-Economic development of J & K headed by the Chief Economic Advisor to the Prime Minister.

Extensively read in European and Indian history and Sufism, Raza had a deep knowledge of human motivation, ethos and culture of both the West and the East.

Moosa Raza authored a book titled “of Nawabs and Nightingales” which is a collection of his early experiences in the Indian Administrative Service.

[18][19] Moosa Raza has also published a collection of his Urdu poems under the title "Khwab-e-Natamaam" (Incomplete Dreams).