[2] The lake as a whole lies at an elevation of 255 metres (837 ft) and covers 1,367 square kilometres (528 sq mi).

Most if not all of the semi-nomadic Cree who originally frequented the area around Moose Lake died in a smallpox epidemic during the winter of 1781–1782.

[4] Tom Lamb operated a cattle ranch at Moose Lake from 1953 to 1964, when flooding of the area by the Grand Rapids hydroelectric project forced its closure.

[5] The building of the Grand Rapids Dam caused the inundation of 66% of the territory held by the Moose Lake Cree, with correspondingly and predictably disastrous consequences for the community: previously important economic activities such as moose hunting were eliminated, and substance abuse among children, crime, and alcoholism had become rampant by the late 1970s.

[6][7] A settlement for damages caused by the Grand Rapids project was signed by the Mosakahiken Cree Nation and the province of Manitoba in 2008.