[1] Located 20 km (13 mi) west of Downtown Buenos Aires, Morón is easily reached via bus along Avenida Rivadavia, via National Highway 7, and the Sarmiento railway line.

A pivotal engagement in the era's Argentine civil wars between Unitarians and Federalists, it resulted in a victory for the Federalists under Juan Manuel de Rosas and the Governor of Santa Fe Province, Estanislao López, over General Juan Lavalle, who was forced to relinquish the governorship he had usurped five months earlier; Rosas' dominion over Buenos Aires Province would continue until 1852.

A large population of Italians settled in Morón subsequently, and in 1867, this community founded the local Mutual Aid Society; Italy would later open a consulate in the city.

Morón was the site of a Radical Civic Union uprising in 1893, during which the National Autonomist Party city government was briefly deposed before federal troops restored the latter to office.

The city is the birthplace of numerous notable figures in Argentine sports, culture, and history, including auto rally champions Diego and Oscar Aventín; the last dictator of Argentina, General Reynaldo Bignone; humorist Diego Capusotto; radio host Beto Casella; Congressmen Martín Sabbatella and Margarita Stolbizer; and Academy Award-winning composer Gustavo Santaolalla.