Famous inhabitants of the district have been Elvira Lindo, Melendi, el Dioni, Alejandro Sanz, "Cleanhead" Joe McGaha,[1] and Letizia Ortiz.

It was located midway on a road that connected Madrid's main cemetery Cementerio de la Almudena with the then unincorporated village of Vallecas.

A military property gave birth to what today is one of the main streets of the district, Calle Del Pico De Los Artilleros.

And an old road connecting Madrid with Castilla La Mancha gave rise to Moratalaz's main avenue, Camino De Los Vinateros.

The distinctive emblem of Public Housing during Franco's dictatorship (a yoke traversed with arrows) can still be found in the older blocks dating from that era.