The brothers successfully resisted the invasion, but at the cost of devastating the countryside of the Morea, and the Turks carrying off 60,000 Greek civilians back to their territory.

[3] Upon the death of Byzantine Emperor John VIII Palaiologos in Constantinople in October 1448, the imperial throne fell to Constantine, who was crowned on 6 January 1449 in Mystras before departing for the capital.

Despite assurances to Constantine that they would pledge support to one another, both Thomas and Demetrios coveted the other's lands – in addition, they pressed claims against Venetian port possessions in the Morea, alienating the only power capable of aiding them in resisting the Turks.

Shortly after the fall of Constantinople and the death of the last Byzantine Emperor Constantine XI, a large-scale revolt broke out among the Moreote Albanians against the two brothers, Thomas and Demetrios, due to the chronic insecurity and tribute payment to the Turks.

The Byzantine contemporary historian George Sphrantzes recorded the resurgence of the last latin dynasty of Achaea in the following short passage: "At Morea, the brother in law of Thomas, the son of Prince Centurione, had escaped from the prison of the Chlemoutsi Castle causing disruption to the region, while the Sultan was concentrated against Serbia".

The siege was initially successful, however as the Sultan's vassals, the despots called upon Turkish aid, and Omar, the son of the Ottoman governor of Thessaly Turakhan Beg, arrived in December 1453.

As for the rebel leaders, Bua was pardoned by Mehmet and later became a spokesperson for the Albanian people, Zaccaria ended up as a pensioner in Venice and later the Papal Court, while Kantakouzenos escaped and disappeared from history.