[4][5] From 2009 to 2015, he served as the Artistic Director of Studio 42, an Off-Off-Broadway theater company whose mission was to produce plays they deemed "unproducible".
[4] Critic Terry Teachout of The Wall Street Journal wrote of Von Stuelpnagel's work, "[His] 2015 Broadway staging of Hand to God proved him to be a master of stage comedy, physical and otherwise.
"[6] Hand to God garnered five Tony Award nominations in 2015, including Best Direction of a Play.
[2] Von Stuelpnagel directed the 2016 production of Hand to God in London's West End at the Vaudeville Theatre where it was nominated for a Laurence Olivier Award for Best New Comedy.
In 2018, von Stuelpnagel directed the premiere on Broadway of Theresa Rebeck's Bernhardt/Hamlet starring Janet McTeer.