In 1902, Morris Sheppard was elected as a Democrat to replace his deceased father in the United States House of Representatives.

In the 1928 presidential election, Texas voters abandoned the Democratic candidate, Alfred E. Smith, Governor of New York and a Catholic, carrying the state for Republican Herbert Hoover and contributing to his victory.

Then-Representative Lyndon B. Johnson ran for Sheppard's Senate seat in the 1941 special election, and lost to Governor W. Lee O'Daniel.

[2] But he supported the maintenance in Texas and the South of racial segregation in public facilities and the disenfranchisement of blacks.

However, during the Prohibition era, a still that produced 130 gallons of moonshine per day was discovered on a Texas ranch that Sheppard owned.

[7] When a resolution calling for a Twenty-first Amendment to repeal prohibition was introduced to the Senate by John J. Blaine of Wisconsin, Sheppard filibustered it for eight-and-a-half hours.

[8] Co-sponsored by Morris Sheppard and Horace Mann Towner, the Sheppard–Towner Act of 1921 provided Federal matching funds for services aimed to reduce maternal and infant mortality.

[9] Senator Morris Sheppard and Congressman Wright Patman are considered the fathers of the Federal Credit Union Act of 1934.

Through their daughter Susan, Sheppard and his wife were the grandparents of Connie Mack III, Republican U.S. Representative and U.S.

Judge Morris Arnold, a Republican, remains on the Eighth Circuit court under senior status.