After finishing school, Meskin went to work for Eisner & Iger, one of the most prominent "packagers" who supplied complete comic books to publishers testing the waters of the emerging medium.
In late 1939, he also worked for the packager Harry "A" Chesler, producing material for the MLJ/Archie Comics characters as Ty-Gor son of Tiger, The Press Guardian, Bob Phantom, Mr. Satan, The Shield, Wizard, and Dick Storm between 1939 and 1942.
In 1949, Meskin left National and joined the Simon & Kirby studio where he worked on a variety of titles such as Boys' Ranch[6] and Prize Comics.
He returned to National in 1956, where he created the feature "Mark Merlin" and also worked on a large number of war, science fiction and horror titles.
In 1965, Meskin left the comics world and became a commercial illustrator and storyboard artist in the advertising industry, working at BBD&O until his retirement in 1982.