The house is considered the finest example of a large Gothic Revival residence still standing in the United States.

Italian immigrant craftsmen were brought via the Wabash and Erie Canal from New York City to execute the plasterwork ceilings in the north and south parlors.

He partnered with Carl Fischer (developer of the Indianapolis Motor Speedway) to build the first luxury hotel in Miami Beach, Florida, which opened on New Year's Eve 1920.

Outside, a large Italian-style tiered patio with fountains, a reflecting pool, a tea house, and formal gardens were added.

From 1940 until 2015, the Moses Fowler House was the home of the Tippecanoe County Historical Association and used at various times as a museum, offices, and for collections storage.