Moses Wisner (June 3, 1815 – January 5, 1863) was the 12th governor of Michigan, a Colonel during the Civil War, and an active supporter of the anti-slavery movement.

In 1841, he was admitted to the bar at Pontiac and then moved to the village of Lapeer, Michigan to begin to a practice.

He was one of the foremost critics in Michigan of the Kansas-Nebraska Act of 1854 which repealed the Missouri Compromise and opened the territories to slavery.

That same year he was an unsuccessful candidate from Michigan's 4th congressional district to the U.S. House against Democrat George Washington Peck.

In September 1862 during the American Civil War, Wisner worked to raise the 22nd Michigan Infantry and was commissioned a colonel, but was stricken with typhoid fever while en route to the regiment's deployment.