Mosesetjane is a village situated northwest of the town of Mokopane in the Waterberg District of the Limpopo province of South Africa.

To the south Mosesetjane is boarded by Masodi, Moshate, and Ga-Madiba.

Sandsloot, Mapela, and the Mogalakwena Platinum Mine are found to the north of this village.

In recent years, the area has seen an influx of immigrants attracted by the platinum mine.

In late 2010 the Mogalakwena Municipality completed a R2,8 million rands tarred road and storm-water drainage system throughout the Malepetleke section of the village.