Mosquero is a village in Harding and San Miguel counties in the U.S. state of New Mexico.

According to the United States Census Bureau, the village has a total area of 1.0 square mile (2.6 km2), all land.

The village was founded in 1908 by Benjamin Brown, and a post office was established here in that year.

[7] The community developed as a farming and stock-raising and shipping point, with a dry ice plant, using carbon dioxide from local wells drilled into the Bravo Dome carbon dioxide gas field, which lies beneath Harding and Union counties.

The railroad, absorbed into the Southern Pacific, was removed in 1950 and the population dwindled after the dry ice plant was destroyed.