Mother Knows Best is a lost 1928 American sound part-talkie film directed by John G. Blystone, based on a novel by Edna Ferber, fictionalizing the life of vaudevillian Elsie Janis.

The film was Fox's first part talkie, using the Movietone sound system which had primarily been used for synchronised music scores and effects tracks in Fox features beforehand, although as early as Mother Machree (1928), a single synchronous singing sequence was included in the film.

The talking sequences in Mother Knows Best were directed by actor Charles Judels,[1][2] while the synchronized sequences were directed by John G. Blystone.

The film starred Madge Bellamy, with Louise Dresser as her domineering mother, Barry Norton, and Albert Gran.

[3] The film featured a theme song entitled "Sally Of My Dreams" which was composed by William Kernell.