Mother Corona, as she was called in her order, was "a builder, administrator, spiritual guide advisor, and Major Superior from 1942–1960".

In 1911 she added a Commercial High School class to the curriculum, which was taught by Sister Clemens Rudolph, who had been trained to teach business courses.

When Mother Stanislaus resigned in 1942, Wirfs was elected Superior General of the Order, which included houses in Germany, Costa Rica, El Salvador, Honduras, India, and China.

[6] As president, responding to pressure from the government requiring teachers to be state-certified, Wirfs opened the college to lay women in 1948.

As Barbaralie Stiefermann, Wirfs' biographer, stated, "At the time of the dedication, newspaper accounts hailed Alverno's present-day campus as a six-million-dollar wonder".

However, a fund drive in 1957 raised only $40,000 of the $500,000 initial goal, so Wirfs and the School Sisters were left with paying the debt.

[14] At the same time, however, congregational leaders worried about bankruptcy caused by the financial obligations incurred by the school.

[21] Later, there was discussion about merging St. Joseph with another hospital run by the Lutheran Church, which would avoid duplication of services and equipment, enhance the quality of care, and attract highly qualified physicians and other personnel.

The Bishop explained that Sisters of Mercy had been teaching in Holy Angels Parish in Chicago, but were no longer able to staff it.

"[26] The following year, in September 1947, a letter from Reverend J.J. Duffin, pastor of Holy Angels Parish to the Cardinal Archbishop reported that Mother Corona had sent two more sisters, and had transferred one sister from Sacred Heart Sanitarium and another who had been a clerk at Madonna High school "to take care of an enrolment of 750 children.

A correspondence began in 1950 with Archbishop Bergan writing, "There is a crying need for a coeducational Catholic high school in South Omaha".

[28] Four years later, in 1954 the archbishop again wrote, asking Wirfs to build a new high school in South Omaha.

[31] In the late 1950s and early 60s, Wirfs needed space in Milwaukee to house the many new applicants who wanted to join the School Sisters.

It opened again in 1969 for retired sisters but closed again in 2002, was sold to the Jesuits for a middle school for Hispanic boys.

[34] On Thursday, January 11, her funeral Mass was celebrated in the convent chapel by William Edward Cousins, Archbishop of Milwaukee, assisted by Monsignor Alex Zuern and Reverends Raymond Parr and Hugh Wish.