Mother Seton House is a historic home located on the grounds of St. Mary’s Seminary at Baltimore, Maryland, United States.

It is a 2+1⁄2-story red brick house, similar to other small homes built in the early 19th century for the predominantly French community nearby.

It was built in 1808 as the home of Elizabeth Ann Seton (1774–1821), the first American-born woman beatified and canonized by the Catholic Church.

In fact, she penned a letter to a friend, Julia Scott, describing it as a "‘neat, delightful mansion, entirely new...in the new French style of folding windows and recesses.’" Despite the fact that Elizabeth Seton only inhabited the home for a year, a long-lasting bond between the two was formed.

[10] After it received negative attention for its lack of upkeep, a local women’s group initiated the restoration of the home.

[4] In the process of renovation, the house was thoroughly documented by taking photos of both the interior and exterior in order to restore the home to its original condition.