He moved to the United States as a teenager to play high school basketball at Prolific Prep Academy.

Gueye played college basketball for the Washington State Cougars and was named to the All-Pac-12 first-team as a sophomore in 2023.

[4] He completed his academic requirements early and reclassified to the 2021 class before he committed to play for the Washington State Cougars over several other high-major offers.

[6] Gueye's role with the Cougars increased during the 2022–23 season following the departure of key pieces of their front-court.

[13] However, on 12 November, he was ruled out for a month after suffering a right lower back stress fracture,[14] subsequently missing most of his rookie season.

[15] Gueye returned from his injury with several stints for the Hawks' NBA G League affiliate, the College Park Skyhawks, both as a rookie and a sophomore.