Moulis-en-Médoc (French pronunciation: [mulis ɑ̃ medɔk], literally Moulis in Médoc; Occitan: Molís de Medòc) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.

The village is situated in the Médoc on a hill, overhanging the Tiquetorte stream, which flows into the Gironde estuary.

In the fourteenth and fifteenth centuries in Haut Médoc, the vine was planted inside rather than at the edge of the estuary to avoid detrimental effects caused by humidity from the river and fog, which can decay and decimate[clarification needed] the vineyards.

The quality of the land was not left unaffected by merchants from Bordeaux, who had made their fortune in the business of islands and invested in Moulis.

The French Revolution did not help the vineyard, but it recovered quickly, reaching its peak at the end of the nineteenth century with an area of 1,500 hectares, before being decimated[clarification needed] by the Phylloxera aphid.