Mound City National Cemetery is a United States National Cemetery located near Mound City, in Pulaski County, Illinois.

Administered by the United States Department of Veterans Affairs, it is managed by the Jefferson Barracks National Cemetery.

[2] This cemetery is listed on the National Register of Historic Places.

During the American Civil War, Mound City was the site of the Mound City Civil War Naval Hospital.

The cemetery was used to inter both Union and Confederate soldiers who died while under care at the hospital.