Very early relations with British settlers were cordial but as farmers started clearing and fencing the land, affecting food resources in the area, clashes between the groups arose until 1816 when a number of indigenous people were massacred and the remainder retreated from direct conflict with the settlers.

After the land was cleared, it was used for farming for most of the next 200 years until Sydney's suburban sprawl reached the town of Camden and modern suburbs like Mount Annan were subdivided into housing blocks.

Mount Annan Christian College (MACC)[7] which was built in 1999 and is located on Narellan Road.

[15] There are also several restaurants in the area including Italian, Thai, Chinese, Japanese, American, and other cuisines.

[16] Mount Annan has an Anytime Fitness gym[17] located on Main Street, and a leisure centre Mount Annan Leisure Centre[18] (which also has a gym) located on Welling Drive.

[23] In the 2021 census, the suburb of Mount Annan had a population of 11,784 people, with 58.0% of couple families having children.

Mount Annan lies in the central ward of Camden Council, currently represented by Rob Mills, Ashleigh Cagney and Theresa Fedeli.