Communities within the district, of which this is the sole comprehensive high school, include Mount Pleasant, Rome, Salem, and Westwood,[2] as well as the census-designated place of Trenton.

The high school is part of the 3A Southeast Conference and participates in 18 varsity athletics, including track and field, cross country, basketball, football, wrestling, volleyball, soccer, tennis, golf, and bowling (added in 2010).

MPCHS holds eight state championships, three in boys basketball (1917, 1918, 2012),[4] one in boys outdoor track & field (2000),[5] girls cross country (2002) and three in girls track & field (2004, 2005, 2006).

[6] The football team was also voted state champions (for all classes) in 1963 (before there was a playoff system) as they were undefeated and unscored on.

The school hosts their own show choir invitational, Music in Motion, annually in early February.