Mount Royal opened its doors in 1960, as one of two Saskatoon west side Public High Schools, the other being Bedford Road Collegiate which was inaugurated in 1923.

With additions of various labs and classrooms, the school has grown to occupy the entire block on Avenue W from Rusholme Road to 29th Street.

Classes are also held in the old Estey Elementary School on Whitney Avenue, where its now called the Royal West Campus.

The school originally offered academic studies until 1967, when it opened to skills education such as a Carpentry and Home Economics class.

The school also provides courses in "English as an Additional Language" (EAL) for new Canadians, Life Skills Work Study (LSWS) programs and a comprehensive offering of vocational and academic programs which are suitable for learners who have diverse learning needs, styles and requirements.