[3] Following its closure as a railroad station in 1961, it became part of the Maryland Institute College of Art, where it now houses the Middendorf Gallery, as well as studio and classroom space for the university's sculpture and fiber departments.

[5] Located at the north end of the B&O's Howard Street tunnel, the station was built of Maryland granite trimmed with Indiana limestone, with a red tile roof and landmark 150-foot (46 m) clocktower.

Luminaries using the B&O's station over the years include U.S. Presidents Woodrow Wilson, Calvin Coolidge, Herbert Hoover, Franklin D. Roosevelt, and Dwight D. Eisenhower, along with Western showman "Buffalo Bill" Cody, singer Enrico Caruso, and celebrated conductor Arturo Toscanini, whose private Pullman car was parked on a siding during his appearances at the nearby Lyric Theatre.

[8] The vacant railroad station building, train shed, and the surrounding 3¼ acres were acquired by the Maryland Institute College of Art (MICA) in 1964 for $250,000.

In 1992, the AIA's Baltimore chapter honored the Maryland Institute and architects Cochran, Stevenson & Donkervoet with a 25 Year Award for Excellence in Design of Enduring Significance for their adaptive reuse of the former train depot.

[citation needed] Between 2005 and 2007, MICA accomplished a two-phased, $6.3 million renovation of the building by the architectural firm of Grieves, Worrall, Wright & O'Hatnick, Inc.

In keeping with the pedestrian landscaping and streetscape that MICA has created along Mount Royal Avenue, a new plaza with benches, bike racks, shrubs, and ornamental grasses and ground cover was added.