[3] In 2007, Mount Sinai West received advanced certification in total hip and knee replacement surgery from The Joint Commission on the Accreditation of Healthcare Organizations (JCAHO).

[8] A plaque to its namesake and benefactor reads: "To the memory of James Henry Roosevelt, a true son of New York, the generous founder of this hospital, a man upright in his aims, simple in his life, and sublime in his benefaction."

[11] Much of the original hospital, including the emergency room, was torn down to make way for two 49-story residential buildings at One Columbus Place.

The emergency room was located in the James Russell Memorial Surgical Building on the corner of 9th Ave and W. 58th Street, and underwent a refurbishment in 1981.

[14] The oldest remaining component of the hospital is the William J. Syms Operating Theater, named after its benefactor, a gun merchant.

On November 17, 2015, St. Luke's–Roosevelt rebranded for the first time in 146 years and christened Mount Sinai West – against the objection of the Roosevelt family.

[31] Deliveries at Mount Sinai West increased 28% between 2016 and 2019; in May 2019, the hospital sought permission from the New York State Department of Health to spend $10.2 million for renovations to the maternity unit.

[32] Mount Sinai West also offers primary care and select clinical specialties at numerous outpatient sites in the surrounding neighborhood of the main hospital.