Men's sports include baseball, basketball, cross country, golf, lacrosse, soccer, swimming & diving, tennis, track & field and water polo; while women's sports include soccer, basketball, bowling, cross country, golf, lacrosse, rugby, softball, swimming & diving, tennis, track & field and water polo.

Mount men's basketball won the 1962 NCAA College Division basketball tournament (the predecessor to the modern Division II tournament) by defeating the Sacramento State Hornets, 58–57, and earned their first NCAA Division I men's basketball tournament win against the Coppin State Eagles in 2008.

The Mountaineers earned regular-season conference titles in 1999, 2001, 2010, 2011, 2019, and 2023, won conference tournament championships in 2001, 2003, 2010, and 2011, and faced the University of Virginia in their 2003 and 2010 NCAA Division I men's lacrosse tournament appearances.

The Mount sponsored men's soccer from 1953 to 2012, participating in the NEC from 1988 to 2012.

Straw Family Stadium, Knott Arena, Morgan Track, Waldron Family Stadium, Our Lady of the Meadows Field, a swimming pool, and tennis courts.