Mount Tweto is set just east of the Continental Divide in the Mosquito Range, which is a subrange of the Rocky Mountains.

Precipitation runoff from the mountain's north and west slopes drains into the headwaters of the East Fork Arkansas River, whereas the south slope drains into the headwaters of Mosquito Creek which is a tributary of the Middle Fork South Platte River.

An ascent of the peak involves hiking seven miles (11 km) with 2,900 feet (884 m) of elevation gain.

[1] The mountain's toponym was officially adopted in 1986 by the United States Board on Geographic Names to honor Ogden L. Tweto (1912–1983), U.S. Geological Survey geologist who spent the major part of his career studying the geology of Colorado, in particular the area of this peak.

[6] Due to its altitude, it receives precipitation all year, as snow in winter and as thunderstorms in summer, with a dry period in late spring.