The Mount Vernon, IL Micropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of one county in southern Illinois, anchored by the city of Mount Vernon.

As of the census[2] of 2000, there were 48,666 people, 18,836 households, and 12,998 families residing within the μSA.

The racial makeup of the μSA was 91.36% White, 6.56% African American, 0.22% Native American, 0.41% Asian, 0.01% Pacific Islander, 0.39% from other races, and 1.05% from two or more races.

Hispanic or Latino of any race were 1.20% of the population.

Males had a median income of $32,977 versus $19,496 for females.