Mountain Home High School is divided into three career academies: Communications, Arts, and Business (CAB), Architecture, Construction, Manufacturing, and Engineering (ACME), and Health and Human Services (HHS).

The assumed course of study follows the Smart Core curriculum developed by the Arkansas Department of Education (ADE), which requires 22 units to graduate and is supplemented by the school's career academies model and Advanced Placement courses and exams.

The Bombers compete in the 6A West Conference in sports such as: football, baseball, basketball (boys/girls), bowling (boys/girls), competitive cheer, cross country (boys/girls), competitive dance, golf (boys/girls), soccer (boys/girls), softball, swimming (boys/girls), tennis (boys/girls), track and field (boys/girls), volleyball, and wrestling.

During the 2004–05 school year, Mountain Home High School students collected more than 6 tons of paper for recycling, and created a model program to promote natural resource conservation.

The Mountain Home High School Band marched in the Macy's Thanksgiving Day Parade, 2006.