The cartoon was animated by Ray Patterson, Irven Spence, Ken Muse and Pete Burness.

Mouse Trouble won the 1944 Oscar for Best Animated Short Film,[2] the second consecutive award bestowed upon the series.

Tom receives a book on catching mice and tries various traps and techniques outlined in it to capture Jerry.

In a final act of desperation, Tom resorts to extreme measures, which ultimately backfire, resulting in his demise.

Meanwhile, Jerry survives the ordeal, leaving Tom's spirit to ascend to the afterlife, still haunted by the book's mocking advice.