The Moussa Dar'i Synagogue (Hebrew: בית הכנסת הקראי בקהיר; Arabic: كنيس موسى الدرعي) is a former Karaite Jewish synagogue or kenesa, located at 25 Sebyl El Khazindar Street, Midan el Gueish, in the Abbasiyah area of the Al-Daher district in western Cairo, Egypt.

[1] n 1900, Sitaytah al-Musaffi, the widow of Sitatah al Musafi (Hebrew: סתתה אל-מספי), donated a large plot of land in the Abbasiyah area to the Jewish community.

[2] The synagogue is named after 12th century Karaite poet and physician Moses ben Abraham Darʿī [he] (Moussa), born in Alexandria, by a suggestion of the community's rabbi, Rav Tuvya.

[2] A long-lost manuscript, the Zechariah Ben ‘Anan, was located at the synagogue in July 2017 by Israeli historian Yoram Meital.

The manuscript was originally written in 1028 CE, was considered to be one of the era’s most complete and well-preserved editions of the third and final book of the Ketuvim.