[5] He made his professional debut with Standard Liège in a 4–0 loss in the Belgian First Division A to Club Brugge on 27 August 2017.

[7][8] On 17 March 2018, Djenepo played when he came on as a substitute for Mehdi Carcela, as Standard Liège beat Genk 1–0 after extra time to win the 2018 Belgian Cup final and qualify for the UEFA Europa League.

[9][10] On 13 June 2019, Djenepo signed a four-year contract with Premier League club Southampton[11][12] for a reported fee of £14 million.

[26] On 5 September 2023, Djenepo rejoined Standard Liège on a three-year contract for an undisclosed fee,[27][28] reported to be around £3 million.

[36] On 23 March 2019, Djenepo scored against South Sudan in a 2019 Africa Cup of Nations qualification home fixture, which ended in a 3–0 victory.