[2][3] Moussa Sène began his career as an actor, but eventually moved on to direct his own play La Légende de Ruba, which he also wrote.

Moussa was honored for his screenplay Les Enfants de Dieu (The Children of God) at the Francophone film festival in Fort-de-France.

[2][4][5] Moussa has made at least ten Senegal related documentaries and he is the songwriter or co-songwriter for all of his films as well as the editor, producer, director and screenwriter.

His style is inspired by the works of Rufino Tamayo and Joan Miró, with elements of the older African technique.

Some of his art works have been exhibited at the Frieda and Roy Furman Gallery at Lincoln Center, New York City.