Mousseaux-sur-Seine (French pronunciation: [muso syʁ sɛn], literally Mousseaux on Seine) is a commune in the Yvelines department in the Île-de-France region in north-central France.

The village is located by the river along a limestone cliff where many were dug basements, "boves" which once served homes.

In pre-Roman Gaul the Belgic tribe of the Veliocasses or Velocasses controlled a large area around the town.

[3] The village was until the late 18th century an important wine production, which remains, still visible, an old press.

After the war the population grew until today it has reached its pre-revolution numbers.