Mouthier-Haute-Pierre (French pronunciation: [mutje ot pjɛʁ]) is a commune in the Doubs department in the Bourgogne-Franche-Comté region in eastern France.

The village is located in the upper Loue valley, just downstream of its source, in a particularly scenic landscape consisting of a natural amphitheatre dominated by steep cliffs.

Other prominent features of the scenery are the 50-metre (160 ft) Syratu Falls, the Gorges de Nouailles, a canyon up to 350 meters deep, the Baume Archée and Faux-Monnayeurs caves and the source of Pontet.

From the eighteenth century, many workshops and mills develop on the banks of the river and the town reach more than 1,000 inhabitants.

Touched by the phylloxera crisis at the end of the nineteenth century, the vineyards were replaced by cherry trees intended to the production of a famous artisanal kirsch.