Mouzieys-Panens is a commune in the Tarn department in southern France.

The village is dominated by a castle that was built in the 12th century by Guillaume de Cadolhe.

In 1566, the castle came into possession of Count Bernard de Rabastens.

In the 18th century the castle was rebuilt and, now demilitarised, it serves as mairie.

Saint Michael's Church at the bottom of the village is a classified monument.