The region's capital was Abengourou and its area was 6,921 km2.

[1] Since 2011, the area formerly encompassed by the region is the second-level Indénié-Djuablin Region in Comoé District.

[2] At the time of its dissolution, Moyen-Comoé Region was divided into three departments: Abengourou, Agnibilékrou, and Bettié.

Moyen-Comoé Region was abolished as part of the 2011 administrative reorganisation of the subdivisions of Ivory Coast.

Indénié-Djuablin is one of two regions in the first-level Comoé District.