Mpanga-Kipengere Game Reserve is a protected area in Njombe Region of the Southern Highlands, Tanzania.

[1] It covers an area of 1,574 km2 (608 sq mi) and ranges in elevation from 1,800 to 2,289 m (5,906 to 7,510 ft).

In addition to the preservation of wildlife the reserve is an important catchment for the headwaters of several rivers that feed into the Great Ruaha River and provide water for the Usangu wetlands.

Endemic species in Mpanga-Kipengere Game Reserve are nosed chameleon, marsh widowbird (Euplectes hartlaubi), churring cisticola (Cisticola njombe), and Kipengere seedeater (Crithagra melanochroa) and Fufumka bird.

The Mpanga-Kipengere Game Reserve is located at the northern end of the Kipengere Range.