The series stars Ted Danson, Bobby Moynihan, Holly Hunter, Vella Lovell, Mike Cabellon, and Kyla Kenedy.

[4] Neil Bremer (Ted Danson) is a wealthy businessman who runs for mayor of Los Angeles "for all the wrong reasons."

Once he wins he has to figure out what he stands for, gain the respect of his staff, and connect with his teenage daughter, all while controlling the coyote population.

[5] On July 18, 2019, it was reported that NBC had given a 13-episode straight-to-series order to an untitled Tina Fey and Robert Carlock comedy starring Ted Danson, who is set to play a wealthy businessman running for mayor of Los Angeles.

Production companies involved with the series include Little Stranger, Bevel Gears, 3 Arts Entertainment and Universal Television.

[5] A first-look tease of the series was included as an end tag on the Peacock stream of "30 Rock: A One-Time Special" uploaded on July 16, 2020.

The website's critics consensus reads, "Mr. Mayor's first term suffers from a lack of specificity, leading to broad jokes and wayward plots—still, a reliably winsome Ted Danson and a silly sensibility may be enough for some viewers.