[1] Many cast members of Saturday Night Live, including Dan Aykroyd, Jane Curtin, Laraine Newman, Bill Murray, Don Novello and Gilda Radner, appear in Mr. Mike's Mondo Video.

Others who appear in the film include musicians Sid Vicious, Paul Shaffer, Debbie Harry, Root Boy Slim, and Klaus Nomi; artist Robert Delford Brown; and model Patty Oja.

[4] Co-writer Mitchell Glazer states in the DVD's audio commentary that many other scenes were added to pad the film's runtime to the required 90 minutes for theatrical releases.

Mondo Video features Sid Vicious performing the classic song "My Way" from The Great Rock 'n' Roll Swindle, which had not yet been released in America at the time.

The sound returns when the performance switches to a heavy punk rock guitar riff, and Sid pulling out a gun, firing (presumably blanks) into the audience, flipping them the bird, and walking off.

"[8] Gene Siskel of the Chicago Tribune gave the film one star out of four and called the humor "sick and stupid," declaring that it was "one case in which the television network is right, and the embattled performer is wrong.

"[10] Bruce Blackadar of the Toronto Star said that "the truth is that not only is Mondo Video a prime candidate for worst movie of the year, it’s also bad television and it deserved to be censored because it’s stupid beyond redemption, joylessly repugnant, a rip-off of the first magnitude.

"[11] Michael Clark of the Detroit Free Press wrote that the film "hit town just one day after the merciful departure of Sammy Stops the World, another theatrically exhibited non-movie whose box-office performance will no doubt have theater owners all over the country pillaging their children's college funds to come up with this month's mortgage payment.

Mike may do marginally better than Sammy, but most viewers will probably agree with the NBC censors who took one look at this slapdash collection of jokes about Gig Young's groceries, Cheryl Tiegs' crotch, and a Cedar Rapids religious cult that worships Jack Lord as a living god and said, 'NO.

'"[12] Mitch Darden of The Indianapolis News said "it's billed as disgusting, disturbing, horrible, raunchy, gross, tasteless and if your children are falling asleep, wake them up to catch this show.

"[14] Robert Alan Rose of the St. Petersburg Times wrote that "two disappointments quickly emerge in Mr. Mike'i Mondo Video, now in local theaters: Mr. Mike—alias Michael O'Donoghue—had nothing to do with writing or filming the animated antics of the clay sculpture, Mr. Bill.

"[15] Greg Tozian of The Tampa Tribune said that "in Mondo Video, a 90-minute grab bag of barf-styled humor that NBC first requested be filmed and finally refused to air (deciding it was "offensive") O'Donohue seems to miss the mark much of the time.

"[17] Walter V. Addiego of the San Francisco Examiner called it "a collection of outrageous skits and jokes that are long on attempted offensiveness and sadly short on humor.

"[18] Ernest Leogrande of the New York Daily News said that the film "evinces a kind of smugness, a suggestion that there are clods on the earth who need to have their conventional minds jolted by ideas that the 'Mondo Video' crowd are able to take in stride.

"Mr. Mike's Mondo Video," shuffled out for national film distribution, is supposed to resemble a sophisticated, wittily satirical "Saturday Night Live."