Mtito Andei is located in Makueni County, in the country's southeastern region, 233 kilometres (145 mi), by road southeast of Nairobi, the capital.

Mtito Andei is a small town on the Mombasa to Nairobi Railway and Highway.

[3] Mtito Andei lies on the main rail line of Kenya Railways, between Mombasa and Nairobi.

Going north west, the road goes through Kibwezi and Sultan Hamud, before entering Nairobi.

The points of interest located in Mtito Andei or close to its borders include the following: